Pakistan's Smarter Retinol Serum — Reduce Wrinkles, Fade Dark Spots & Refine Skin Texture Without the Irritation. Every Night.

Retinol is dermatology's most proven anti-aging ingredient — but for most people, traditional retinol causes redness, peeling, and irritation that makes it impossible to use consistently. Retinew Serum by Esthetic Sciences solves this. Powered by Encapsulated Retinol 0.5%, Retinew uses micro-encapsulation technology to wrap each retinol molecule in a protective shell that releases slowly into the skin — delivering the same powerful anti-aging results with significantly less irritation, making it safe for everyday use, even on sensitive skin. Paired with Matrixyl 3000 (a collagen-stimulating peptide) and Squalane (a deep-hydration lipid), Retinew is a complete overnight anti-aging serum engineered for real, visible skin transformation.

Whether you are targeting stubborn fine lines, uneven skin tone, enlarged pores, or post-acne dark spots, Retinew's triple-active formula works through the night to visibly transform your skin over time. Its slow-release encapsulation technology makes it the ideal choice for first-time retinol users easing into the ingredient, sensitive skin types who have avoided retinol out of fear of irritation, and experienced users seeking a stable, effective daily-use retinol serum. Formulated by Esthetic Sciences for women and men aged 25–55+ across Lahore, Karachi, Islamabad, Rawalpindi, and all of Pakistan.

Why Choose Retinew Anti-Aging Retinol Serum?

• Encapsulated Retinol — Smarter, Safer Delivery: Unlike traditional retinol that deposits all at once causing redness and peeling, Retinew's micro-encapsulation technology releases retinol slowly into the skin — giving you the same anti-aging power with significantly less irritation. A smarter retinol for everyday use.
• Reduces Fine Lines & Wrinkles: Retinol is one of the most clinically validated anti-aging actives in dermatology. Retinew's 0.5% encapsulated retinol stimulates cellular turnover and collagen synthesis overnight — progressively smoothing fine lines and softening deep wrinkles with consistent use.
• Smooths & Refines Skin Texture: Rough, uneven skin surface caused by aging, sun damage, and congested pores is progressively refined with Retinew's nightly retinol action — accelerating cell renewal for a visibly smoother, more even complexion over time.
• Fades Dark Spots & Hyperpigmentation: Retinol accelerates skin cell turnover, pushing pigmented cells to the surface and replacing them with fresh, even-toned skin. Retinew targets post-acne marks, sun spots, and age-related hyperpigmentation for a brighter, more uniform skin tone.
• Boosts Collagen Production with Matrixyl 3000: Matrixyl 3000 — a clinically proven peptide complex — signals the skin to produce more collagen and elastin, improving skin firmness, elasticity, and structural density. Works synergistically with retinol to restore youthful skin architecture.
• Minimises Enlarged Pores: By promoting cellular turnover and clearing the dead skin and sebum build-up that stretches pore walls, Retinew helps visibly tighten and refine enlarged pores — especially effective for combination and oily skin types.
• Evens Out Skin Tone: The combination of retinol's brightening action and Matrixyl 3000's skin-renewal properties works to progressively even out patchy, dull, or discoloured skin tone — restoring a more radiant, uniform complexion.
• Gentle Enough for Sensitive Skin: The slow-release encapsulation formula prevents the irritation spike of traditional retinol — making Retinew suitable for sensitive, reactive, and first-time retinol users who have previously been unable to tolerate retinol products.
• Deep Hydration with Squalane: Squalane — a stable, skin-identical lipid — delivers intense moisture without greasiness, reinforcing the skin's barrier and preventing the dryness and tightness commonly associated with retinol use. Your skin stays nourished throughout the overnight treatment.

Who Is Retinew Serum For?

Retinew is formulated for anyone aged 25–55+ dealing with visible signs of aging, uneven skin, or looking to begin a science-backed anti-aging routine. It is the right overnight serum if you are:

• Women in Their Late 20s — Early Anti-Aging Prevention: The 25–30 age range is the ideal time to start retinol. Retinew's gentle encapsulated formula is the perfect introduction — building collagen reserves and preventing fine lines before they deepen.
• Women in Their 30s — Targeting Fine Lines & Uneven Tone: Early visible aging, post-pregnancy skin changes, and hormonal pigmentation in the 30s respond well to consistent overnight retinol use. Retinew's triple-active formula tackles texture, tone, and fine lines simultaneously.
• Mature Skin 40+ — Reducing Wrinkles & Restoring Firmness: For women and men 40 and above, Retinew's Matrixyl 3000 + Encapsulated Retinol combination targets deeper wrinkles, loss of firmness, and significant collagen decline — the most visible signs of mature skin aging.
• Sensitive Skin Types Who Have Avoided Retinol: If redness, peeling, and irritation from previous retinol attempts have put you off, Retinew's slow-release encapsulation technology is specifically designed for you — the same results, without the sensitisation.
• First-Time Retinol Users — Introducing the Ingredient Safely: Retinew is the ideal first retinol serum. Its encapsulated 0.5% formula is strong enough to deliver visible results yet gentle enough for gradual skin introduction — easing first-timers into retinol without overwhelming the skin barrier.
• People with Dark Spots, Post-Acne Marks & Hyperpigmentation: Whether caused by sun exposure, post-acne scarring, hormonal changes, or aging, Retinew's retinol and peptide combination progressively fades pigmentation and restores an even, brighter skin tone over consistent overnight use.
• Oily & Combination Skin with Enlarged Pores: Retinol's cellular turnover action combined with Retinew's squalane-based hydration is highly effective for oily and combination skin — visibly refining enlarged pores and balancing skin texture without stripping the moisture barrier.
• Anyone Building a Collagen-Boosting AM/PM Routine: Pair Retinew (PM) with a Vitamin C serum (AM) for a clinically-aligned collagen-boosting protocol — the gold standard anti-aging combination recommended by dermatologists worldwide.
• Buyers Across Pakistan — Lahore, Karachi, Islamabad & Rawalpindi: Pakistan's climate — intense UV exposure, humidity, and pollution — accelerates skin aging and hyperpigmentation. Retinew's daily-use retinol formula is a practical, accessible overnight solution for anti-aging skin management across Pakistan's major cities.
• Gifting — Premium Skincare Gift for Anti-Aging Occasions: A sophisticated, results-driven gift for Eid, birthdays, and special occasions — a clinically formulated anti-aging serum that will be genuinely valued by any skincare-conscious recipient.

What Makes Retinew Serum Unique?

• Micro-Encapsulated Retinol Technology: Retinol wrapped in a protective delivery shell — slow release into skin means the same anti-aging power with dramatically less irritation. No other delivery method compares.
• 0.5% Retinol — Clinically Effective Concentration: 0.5% is the dermatologist-recommended sweet spot — strong enough for visible results, gentle enough for daily overnight use without over-sensitising the skin.
• Triple-Active Synergy — Retinol + Matrixyl 3000 + Squalane: Three actives working in complementary pathways: retinol for cellular renewal, Matrixyl 3000 for collagen stimulation, Squalane for barrier hydration — comprehensive anti-aging in one formula.
• 6-in-1 Skin Concern Coverage: Fine lines, wrinkles, texture, dark spots, enlarged pores, and uneven tone — all addressed in a single nightly application. No need for multiple anti-aging products.
• Sensitive Skin Inclusive Formulation: The encapsulation technology makes Retinew usable by the significant portion of the population who cannot tolerate standard retinol — expanding access to retinol's proven benefits.
• Dedicated Overnight Repair Formula: Formulated exclusively for nighttime use when skin's natural repair cycle is at its most active — maximising active ingredient efficacy during the optimal biological window.
• Esthetic Sciences — Clinical Skincare Standard: Formulated with pharmaceutical-grade actives at clinically validated concentrations — professional-level skincare made accessible across Pakistan.
• Collagen-Boosting Protocol Compatible: Retinew is designed to complement Vitamin C serums in AM/PM routines — fitting seamlessly into the gold-standard anti-aging protocol recommended by dermatologists.

Key Active Ingredients

Retinew Serum's efficacy is built on three clinically chosen actives, each targeting skin aging through a distinct biological mechanism:

• Encapsulated Retinol 0.5% (Micro-Encapsulated Vitamin A): Retinol is the gold standard of evidence-based anti-aging skincare — decades of clinical research confirm its ability to stimulate collagen production, accelerate cellular turnover, fade pigmentation, and reduce fine lines. Retinew uses micro-encapsulation technology to protect each retinol molecule in a lipid shell that slowly dissolves into the skin — releasing the active gradually for sustained results with significantly less irritation, redness, or peeling than traditional retinol. This makes it suitable for daily overnight use, even by those with sensitive or reactive skin.
• Matrixyl 3000 (Collagen-Stimulating Peptide Complex): Matrixyl 3000 is one of the most studied and validated anti-wrinkle peptides in cosmetic science. Composed of two matrikine peptides — Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 — it signals dermal fibroblasts to produce more collagen, elastin, and hyaluronic acid, restoring the skin's structural matrix that depletes with age. Clinical studies have shown Matrixyl 3000 can significantly reduce the volume and depth of wrinkles with consistent use. Its mechanism complements retinol's action for a synergistic anti-aging effect.
• Squalane (Skin-Identical Hydration Lipid): Squalane is a stable, lightweight, skin-identical lipid that mimics the skin's own natural oils. It delivers deep, non-greasy moisture that prevents the transepidermal water loss commonly associated with retinol use — maintaining skin barrier integrity, preventing dryness and tightness, and leaving skin soft and supple throughout the overnight treatment. Unlike heavier oils, Squalane absorbs completely without residue, making Retinew comfortable for all skin types including oily and combination.

Product Specifications

Suitable Skin Types:

How to Use Retinew Anti-Aging Retinol Serum

When & How to Use Retinew Serum

Frequently Asked Questions

Important Warnings & Usage Instructions

• For External Use Only. Apply to face and neck only. Avoid contact with eyes, lips, and mucous membranes. If accidental eye contact occurs, rinse immediately and thoroughly with clean water.
• Morning SPF is Mandatory: Retinol significantly increases photosensitivity. Never skip broad-spectrum SPF 30+ sunscreen the morning after use — unprotected sun exposure will cause skin sensitivity, UV-induced pigmentation, and will counteract the anti-aging and brightening results.
• First-Time Retinol Users — Start Slowly: Begin with 2–3 nights per week for the first 2–3 weeks and gradually increase frequency. Even with encapsulated retinol's gentler delivery, skin needs time to build retinol tolerance. Do not exceed the recommended usage frequency during the acclimatisation period.
• Patch Test Recommended: If you have extremely reactive, allergy-prone, or compromised skin, perform a patch test on a small area (inner forearm or behind the ear) 24 hours before full facial application to check for any adverse reaction.
• Do Not Use on Broken, Severely Irritated, or Sunburned Skin: Avoid application on open wounds, active eczema flares, severely inflamed or sunburned skin, or any compromised skin barrier without dermatologist guidance.
• Avoid Combining with Other Strong Actives on the Same Night: Do not layer Retinew Serum with other retinoids, AHA/BHA acids (Glycolic Acid, Mandelic Acid, Salicylic Acid), or strong exfoliants on the same night — this can cause over-sensitisation, irritation, and barrier damage.
• Not Recommended During Pregnancy or Breastfeeding: Retinol (Vitamin A derivatives) are not recommended for use during pregnancy or breastfeeding. Consult your healthcare provider or dermatologist for safe alternatives during this period.
• Keep Out of Reach of Children. Not intended for use by children under 18 years of age. Consult a dermatologist before use on adolescents.
• Store in a Cool, Dry Place Away from Direct Sunlight: Retinol is sensitive to light and heat. Store Retinew Serum in a cool, dry location away from direct sunlight and humidity to maintain active ingredient stability and product efficacy. Keep cap tightly closed after each use.
• Consult a Dermatologist for Severe Skin Conditions: Retinew is formulated for general anti-aging use. If you have severe or active inflammatory skin conditions, rosacea, eczema, psoriasis, or any dermatological diagnosis, consult a dermatologist before introducing any retinol product.